Physiological Roles of Corticotropin-Releasing Hormone Receptor Type 2.
نویسندگان
چکیده
منابع مشابه
Physiological Roles Receptor Type 2 of Corticotropin -Releasing Hormone
Corticotropin-releasing hormone (CRH) is a key mediator of endocrine, autonomic, behavioral, and immune responses to stress. In response to stress, CRH released from the hypothalamic paraventricular nucleus (PVN) activates CRH receptor on the anterior pituitary corticotrophes, resulting in secretion of adrenocorticotropic hormone (ACTH) into the bloodstream. Two CRH receptors, CRH-receptor type...
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Stress is a reaction to unwanted events disturbing body homeostasis which influences its pathways and target areas. Stress affects the brain through the lateral hypothalamic area (LHA) orexinergic system that mediates the effect of corticotropin-releasing hormone (CRH) through CRH receptor type 1 (CRHr1). Therefore, this study explores the outcome of stress exposure on anxiety development and t...
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Heart failure occurs when the heart is unable to effectively pump blood and maintain tissue perfusion. Despite numerous therapeutic advancements over previous decades, the prognosis of patients with chronic heart failure remains poor, emphasizing the need to identify additional pathophysiological factors. Here, we show that corticotropin releasing hormone receptor 2 (Crhr2) is a G protein-coupl...
متن کامل[Molecular analysis of the corticotropin-releasing hormone receptor type 2 gene fragment in anorexia nervosa].
INTRODUCTION There is strong evidence for the importance of genetic factors in the aetiology of anorexia nervosa (AN). Stress factors can be also associated with the clinical manifestation of AN. The hypothalamic-pituitary-adrenal axis plays an important role in stress control. The increased activity of the hypothalamic-pituitary-adrenal axis in AN is caused by corticotropin-releasing hormone h...
متن کاملCorticotropin-releasing hormone physiology
Corticotropin-releasing hormone (CRH), also known as corticotropin-releasing factor, is a highly conserved peptide hormone comprising 41 amino acid residues. Its name derives from its role in the anterior pituitary, where it mediates the release of corticotropin (ACTH) leading to the release of adrenocortical steroids. CRH is the major hypothalamic activator of the hypothalamic–pituitary– adren...
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ژورنال
عنوان ژورنال: Endocrine Journal
سال: 2001
ISSN: 0918-8959,1348-4540
DOI: 10.1507/endocrj.48.1